ACTIVIDAD FISICA: IMPORTANCIA, RELACION Y EFECTOS EN CANCER

En CAM World Congress 2017 la ponencia del  doctor Thomas Fisher de New Jersey University,  destacó  la relación del ejercicio, el tejido conectivo las fascias  y el cáncer y cómo los tratamientos con actividad física puedan incrementar las respuestas de alivio natural.  La posibilidad de que las fuerzas mecánicas producidas en los tejidos durante el ejercicio, podrían impactar directamente el crecimiento tumoral o la recurrencia.  En palabras simples, la compresión de las células metastásicas circulantes en la vasculatura de los tejidos musculares,  por medio de ejercicio vigoroso contra resistencia, podría causar daños mecánicos que causarían muerte celular.

Los invitamos a consultar con mayor detalle los postulados del Dr. Finley en el enlace www.reseaerchgate.net/profile/Thomas_Findley

“Physical-based treatments that impact connective tissue have the potential to influence tumor growth, spreading and metastasis through mechanisms explored in the emerging role of connective tissue in cancer biology. Recent advances in understanding the effect of mechanical forces on tissues provide clues that may now be useful to understand the biology of physical-based therapies in relation to cancer and perhaps eventually develop physical treatments that may enhance natural healing responses. the possibility that mechanical forces produced within tissues during exercise could directly impact tumor growth or recurrence has received little attention. While the safety of applying direct mechanical forces in the vicinity of tumors is a prime concern, active or passive mechanical forces applied away from the tumor itself may promote a healthy connective tissue environment throughout the body that is inhospitable to cancer and enhances natural immunity. Thomas DeLorme is known for the progressive resistance exercise (PRE) protocol. However, many have overlooked or forgotten the fact that although DeLorme exercised patients through the full range of motion, he did so in a way that the muscle was maximally loaded when at its shortened length. My latest research explores short muscle length loading programs, with outcome measures such as range of motion, muscle length, soft tissue pliability and long-term function changes.”.

Desde un abordaje molecular, el tema es tratado en la prestigiosa “Nature Cancer Review”  en su primer número de Octubre de 2017;  tratando de dilucidar los mecanismos mediante los cuales el ejercicio contribuye en forma benéfica a la modificación del medio ambiente tumoral

“The integrity and composition of the tumour microenvironment (TME) is highly plastic, undergoing constant remodelling in response to instructive signals derived from alterations in the availability and nature of systemic host factors. This ‘systemic milieu’ is directly modulated by host exposure to modifiable lifestyle factors such as exercise. Host exposure to regular exercise markedly reduces the risk of the primary development of several cancers and might improve clinical outcomes following a diagnosis of a primary disease. However, the molecular mechanisms that underpin the apparent antitumour effects of exercise are poorly understood. In this Opinion article, we explore the putative effects of exercise in reprogramming the interaction between the host and the TME. Specifically, we speculate on the possible effects of exercise on reprogramming ‘distant’ tissue microenvironments (those not directly involved in the exercise response) by analysing how alterations in the systemic milieu might modulate key TME components to influence cancer hallmarks.”

Nature Reviews Cancer 17,620–632 (2017)

doi:10.1038/nrc.2017.78

Published online 25 September 2017